High-dose folic acid improves endothelial function by increasing tetrahydrobiopterin and decreasing homocysteine levels
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چکیده
منابع مشابه
Folic acid improves endothelial function in coronary artery disease via mechanisms largely independent of homocysteine lowering.
BACKGROUND Homocysteine is a risk factor for coronary artery disease (CAD), although a causal relation remains to be proven. The importance of determining direct causality rests in the fact that plasma homocysteine can be safely and inexpensively reduced by 25% with folic acid. This reduction is maximally achieved by doses of 0.4 mg/d. High-dose folic acid (5 mg/d) improves endothelial function...
متن کاملLargely Independent of Homocysteine Lowering Folic Acid Improves Endothelial Function in Coronary Artery Disease via Mechanisms
Sagar N. Doshi, Ian F.W. McDowell, Stuart J. Moat, Nicola Payne, Hilary J. Durrant, Malcolm Largely Independent of Homocysteine Lowering Folic Acid Improves Endothelial Function in Coronary Artery Disease via Mechanisms Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2002 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenvi...
متن کاملInfluence of folic acid on plasma homocysteine levels & arterial endothelial function in patients with unstable angina.
BACKGROUND & OBJECTIVE High plasma homocysteine (Hcy) levels are known to be associated with coronary artery disease, but the precise level associated with an increased risk is yet controversial. Whether the beneficial effects of folic acid on arterial endothelial function persist over longer periods is not known. This study was carried out to assess whether folic acid supplementation could pro...
متن کاملFolic acid improves arterial endothelial function in adults with hyperhomocystinemia.
OBJECTIVES To evaluate whether oral folic acid supplementation might improve endothelial function in the arteries of asymptomatic adults with hyperhomocystinemia. BACKGROUND Hyperhomocystinemia is an independent risk factor for endothelial dysfunction and occlusive vascular disease. Folic acid supplementation can lower homocystine levels in subjects with hyperhomocystinemia; however, the effe...
متن کاملReduction of total homocysteine levels by oral folic acid fails to improve endothelial function in children with chronic renal failure.
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ژورنال
عنوان ژورنال: Molecular Medicine Reports
سال: 2014
ISSN: 1791-2997,1791-3004
DOI: 10.3892/mmr.2014.2332